BRD-A72180425_K784-3188_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-A72180425_K784-3188_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ANXA1 annexin A1
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAALC brain and acute leukemia, cytoplasmic
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNL1 cyclin L1
CD38 CD38 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLDN7 claudin 7
COL9A2 collagen, type IX, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
GBP2 guanylate binding protein 2, interferon-inducible
GRB7 growth factor receptor-bound protein 7
H1F0 H1 histone family, member 0
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2A myocyte enhancer factor 2A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBPL1A oxysterol binding protein-like 1A
PCDH9 protocadherin 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTEN phosphatase and tensin homolog
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALGDS ral guanine nucleotide dissociation stimulator
RB1CC1 RB1-inducible coiled-coil 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPP1 uridine phosphorylase 1
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ANAPC13 anaphase promoting complex subunit 13
ARL3 ADP-ribosylation factor-like 3
ARMCX2 armadillo repeat containing, X-linked 2
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CBR3 carbonyl reductase 3
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CD59 CD59 molecule, complement regulatory protein
CETN2 centrin, EF-hand protein, 2
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COASY CoA synthase
COG2 component of oligomeric golgi complex 2
CPB1 carboxypeptidase B1 (tissue)
CPVL carboxypeptidase, vitellogenic-like
CTSC cathepsin C
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EDN1 endothelin 1
EED embryonic ectoderm development
F2R coagulation factor II (thrombin) receptor
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBLN1 fibulin 1
FBXO9 F-box protein 9
FEN1 flap structure-specific endonuclease 1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCA grancalcin, EF-hand calcium binding protein
HIST1H4C histone cluster 1, H4c
HOXA10 homeobox A10
IGFBP7 insulin-like growth factor binding protein 7
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLHL9 kelch-like family member 9
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAGED1 melanoma antigen family D1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MTMR1 myotubularin related protein 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PCTP phosphatidylcholine transfer protein
PDGFC platelet derived growth factor C
PDZK1 PDZ domain containing 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLXNC1 plexin C1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RRAGA Ras-related GTP binding A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SFRP1 secreted frizzled-related protein 1
SLC35E3 solute carrier family 35, member E3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D16 TBC1 domain family, member 16
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TRAPPC4 trafficking protein particle complex 4
TYRP1 tyrosinase-related protein 1
VCAN versican
WBP1L WW domain binding protein 1-like
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF185 zinc finger protein 185 (LIM domain)
ZNF652 zinc finger protein 652