BRD-A71459254_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-A71459254_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CCNL1 cyclin L1
CDC42 cell division cycle 42
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC5A C-type lectin domain family 5, member A
CLPTM1 cleft lip and palate associated transmembrane protein 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSV cathepsin V
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
EREG epiregulin
EZR ezrin
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
H1FX H1 histone family, member X
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
ITGA8 integrin, alpha 8
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
LAMP1 lysosomal-associated membrane protein 1
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1G metallothionein 1G
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NRG1 neuregulin 1
NUPL1 nucleoporin like 1
PAWR PRKC, apoptosis, WT1, regulator
PDE8B phosphodiesterase 8B
PDLIM5 PDZ and LIM domain 5
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SASH1 SAM and SH3 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
SST somatostatin
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX10 testis expressed 10
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALAD aminolevulinate dehydratase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA6 annexin A6
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
B3GNT1
BRCA1 breast cancer 1, early onset
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
COG2 component of oligomeric golgi complex 2
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
EVL Enah/Vasp-like
FAM107A family with sequence similarity 107, member A
FANCF Fanconi anemia, complementation group F
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
LTA4H leukotriene A4 hydrolase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MAT2A methionine adenosyltransferase II, alpha
MET MET proto-oncogene, receptor tyrosine kinase
METTL13 methyltransferase like 13
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NREP neuronal regeneration related protein
NUP37 nucleoporin 37kDa
PLAT plasminogen activator, tissue
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRUNE2 prune homolog 2 (Drosophila)
PWP1 PWP1 homolog (S. cerevisiae)
RAB31 RAB31, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE6 ribonuclease, RNase A family, k6
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
TBC1D16 TBC1 domain family, member 16
TBC1D31 TBC1 domain family, member 31
THYN1 thymocyte nuclear protein 1
TMEM176B transmembrane protein 176B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
USP34 ubiquitin specific peptidase 34
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF185 zinc finger protein 185 (LIM domain)
ZNF302 zinc finger protein 302