BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_NCIH2073_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

191 genes differentially expressed following the BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_NCIH2073_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMACR alpha-methylacyl-CoA racemase
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAX BCL2-associated X protein
BLCAP bladder cancer associated protein
C2CD2 C2 calcium-dependent domain containing 2
CCL2 chemokine (C-C motif) ligand 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CST3 cystatin C
CTSB cathepsin B
CXCL13 chemokine (C-X-C motif) ligand 13
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DFNA5 deafness, autosomal dominant 5
DUSP14 dual specificity phosphatase 14
E2F2 E2F transcription factor 2
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPC1 glypican 1
GSN gelsolin
HCP5 HLA complex P5 (non-protein coding)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1RN interleukin 1 receptor antagonist
INPP1 inositol polyphosphate-1-phosphatase
KRT6A keratin 6A, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRP10 low density lipoprotein receptor-related protein 10
MED24 mediator complex subunit 24
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM1 PDZ and LIM domain 1
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS27L ribosomal protein S27-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
SASH3 SAM and SH3 domain containing 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFN stratifin
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SOCS2 suppressor of cytokine signaling 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TRIM22 tripartite motif containing 22
WDR45 WD repeat domain 45
WFS1 Wolfram syndrome 1 (wolframin)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG6 adhesion G protein-coupled receptor G6
ALB albumin
ANXA1 annexin A1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF106 chromosome 1 open reading frame 106
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CFI complement factor I
CLC Charcot-Leyden crystal galectin
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
CSRP1 cysteine and glycine-rich protein 1
DAPK1 death-associated protein kinase 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPYD dihydropyrimidine dehydrogenase
EPHA3 EPH receptor A3
EVI2A ecotropic viral integration site 2A
FAM64A family with sequence similarity 64, member A
FBXO5 F-box protein 5
FGG fibrinogen gamma chain
FRZB frizzled-related protein
GPC3 glypican 3
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KYNU kynureninase
LUM lumican
LXN latexin
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MDFIC MyoD family inhibitor domain containing
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
OIP5 Opa interacting protein 5
ORC1 origin recognition complex, subunit 1
PARPBP PARP1 binding protein
PBK PDZ binding kinase
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLK1 polo-like kinase 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTPRO protein tyrosine phosphatase, receptor type, O
RGS2 regulator of G-protein signaling 2
SAP30 Sin3A-associated protein, 30kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SLC38A1 solute carrier family 38, member 1
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCP1 t-complex 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
VNN1 vanin 1