BRD-A68930007_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

312 genes differentially expressed following the BRD-A68930007_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP13 A kinase (PRKA) anchor protein 13
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIRIN1 akirin 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX1 brain expressed, X-linked 1
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CCL20 chemokine (C-C motif) ligand 20
CDK17 cyclin-dependent kinase 17
CENPE centromere protein E, 312kDa
CHN1 chimerin 1
CLEC11A C-type lectin domain family 11, member A
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CRY1 cryptochrome circadian clock 1
CSRP2 cysteine and glycine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCP1A decapping mRNA 1A
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP1 dual specificity phosphatase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
EZR ezrin
FAM46A family with sequence similarity 46, member A
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GLUL glutamate-ammonia ligase
GPATCH8 G patch domain containing 8
H1F0 H1 histone family, member 0
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
ITCH itchy E3 ubiquitin protein ligase
JMJD1C jumonji domain containing 1C
KAT6A K(lysine) acetyltransferase 6A
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0907 KIAA0907
KIDINS220 kinase D-interacting substrate, 220kDa
KLHL24 kelch-like family member 24
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKRN1 makorin ring finger protein 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MTF2 metal response element binding transcription factor 2
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPIPB3 nuclear pore complex interacting protein family, member B3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPL1 nucleoporin like 1
PKN2 protein kinase N2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNISR PNN-interacting serine/arginine-rich protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PRRC2C proline-rich coiled-coil 2C
PSME4 proteasome (prosome, macropain) activator subunit 4
PTBP2 polypyrimidine tract binding protein 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QKI QKI, KH domain containing, RNA binding
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RBM5 RNA binding motif protein 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RNF11 ring finger protein 11
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEC24A SEC24 family member A
SEC62 SEC62 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SON SON DNA binding protein
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SWAP70 SWAP switching B-cell complex 70kDa subunit
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TMF1 TATA element modulatory factor 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRA2A transformer 2 alpha homolog (Drosophila)
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNL4B thioredoxin-like 4B
UBAP1 ubiquitin associated protein 1
UBXN7 UBX domain protein 7
USP47 ubiquitin specific peptidase 47
WIPF2 WAS/WASL interacting protein family, member 2
XIST X inactive specific transcript (non-protein coding)
ZNF292 zinc finger protein 292
ZNF430 zinc finger protein 430
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADSL adenylosuccinate lyase
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGR2 anterior gradient 2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA4 annexin A4
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CANT1 calcium activated nucleotidase 1
CBS cystathionine-beta-synthase
CCDC85B coiled-coil domain containing 85B
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHMP4A charged multivesicular body protein 4A
CHMP7 charged multivesicular body protein 7
COA3 cytochrome c oxidase assembly factor 3
COG4 component of oligomeric golgi complex 4
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPNE3 copine III
CRYAB crystallin, alpha B
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCPS decapping enzyme, scavenger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DES desmin
DLAT dihydrolipoamide S-acetyltransferase
DLD dihydrolipoamide dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
FANCF Fanconi anemia, complementation group F
FCGBP Fc fragment of IgG binding protein
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS2L1 growth arrest-specific 2 like 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GYG1 glycogenin 1
HADH hydroxyacyl-CoA dehydrogenase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGL immunoglobulin lambda locus
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS3 integrator complex subunit 3
ITGB1BP1 integrin beta 1 binding protein 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LAGE3 L antigen family, member 3
LAMA5 laminin, alpha 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEH1 melanoma antigen family H1
MAVS mitochondrial antiviral signaling protein
MB myoglobin
MCM6 minichromosome maintenance complex component 6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGST2 microsomal glutathione S-transferase 2
MLPH melanophilin
MOCS2 molybdenum cofactor synthesis 2
MRPL15 mitochondrial ribosomal protein L15
MRPL24 mitochondrial ribosomal protein L24
MRPS33 mitochondrial ribosomal protein S33
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSMB microseminoprotein, beta-
MSRB2 methionine sulfoxide reductase B2
MYBPC1 myosin binding protein C, slow type
MYH11 myosin, heavy chain 11, smooth muscle
NBN nibrin
NCAPD3 non-SMC condensin II complex, subunit D3
NEB nebulin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NPEPL1 aminopeptidase-like 1
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NUDCD3 NudC domain containing 3
NUP37 nucleoporin 37kDa
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPA2 pyrophosphatase (inorganic) 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS23 protease, serine, 23
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB31 RAB31, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RMDN1 regulator of microtubule dynamics 1
RNASET2 ribonuclease T2
RPP40 ribonuclease P/MRP 40kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RUVBL1 RuvB-like AAA ATPase 1
SAMM50 SAMM50 sorting and assembly machinery component
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC2A4RG SLC2A4 regulator
SPDEF SAM pointed domain containing ETS transcription factor
STAMBP STAM binding protein
STEAP3 STEAP family member 3, metalloreductase
STS steroid sulfatase (microsomal), isozyme S
SYNGR2 synaptogyrin 2
SYNM synemin, intermediate filament protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TFF1 trefoil factor 1
THYN1 thymocyte nuclear protein 1
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRIOBP TRIO and F-actin binding protein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN6 tetraspanin 6
TST thiosulfate sulfurtransferase (rhodanese)
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TWF2 twinfilin actin binding protein 2
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
URI1 URI1, prefoldin-like chaperone
UROS uroporphyrinogen III synthase
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZIC1 Zic family member 1
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein