BRD-A68930007_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A68930007_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG6 adhesion G protein-coupled receptor G6
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF1 activating transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP7 fatty acid binding protein 7, brain
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GRB14 growth factor receptor-bound protein 14
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IRS2 insulin receptor substrate 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0226L KIAA0226-like
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MBNL1 muscleblind-like splicing regulator 1
MGP matrix Gla protein
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAWR PRKC, apoptosis, WT1, regulator
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PUF60 poly-U binding splicing factor 60KDa
QKI QKI, KH domain containing, RNA binding
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RLF rearranged L-myc fusion
S100P S100 calcium binding protein P
SALL1 spalt-like transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF11 SR-related CTD-associated factor 11
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SOD2 superoxide dismutase 2, mitochondrial
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D4 TBC1 domain family, member 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM123 transmembrane protein 123
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNL4B thioredoxin-like 4B
VLDLR very low density lipoprotein receptor
WWC2 WW and C2 domain containing 2
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADA adenosine deaminase
ANXA4 annexin A4
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNF cyclin F
CD248 CD248 molecule, endosialin
CDC25B cell division cycle 25B
CLTC clathrin, heavy chain (Hc)
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
ELN elastin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD6 FXYD domain containing ion transport regulator 6
GAS1 growth arrest-specific 1
GSPT2 G1 to S phase transition 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ITGB1BP1 integrin beta 1 binding protein 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LINC00342 long intergenic non-protein coding RNA 342
LPAR1 lysophosphatidic acid receptor 1
LRRC15 leucine rich repeat containing 15
MAB21L1 mab-21-like 1 (C. elegans)
MAPT microtubule-associated protein tau
MAT2A methionine adenosyltransferase II, alpha
MFAP4 microfibrillar-associated protein 4
MME membrane metallo-endopeptidase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PPA1 pyrophosphatase (inorganic) 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SNX7 sorting nexin 7
STEAP3 STEAP family member 3, metalloreductase
STK39 serine threonine kinase 39
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TOB1 transducer of ERBB2, 1
ZIC1 Zic family member 1
ZNF395 zinc finger protein 395