BRD-A68061604_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A68061604_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
F5 coagulation factor V (proaccelerin, labile factor)
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
GDF15 growth differentiation factor 15
H1F0 H1 histone family, member 0
H2AFV H2A histone family, member V
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
JUP junction plakoglobin
LDLR low density lipoprotein receptor
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NTS neurotensin
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTCH1 patched 1
QPRT quinolinate phosphoribosyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SQLE squalene epoxidase
SYNE2 spectrin repeat containing, nuclear envelope 2
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANPEP alanyl (membrane) aminopeptidase
BMP2 bone morphogenetic protein 2
CCND1 cyclin D1
CD93 CD93 molecule
CELF2 CUGBP, Elav-like family member 2
CRYAB crystallin, alpha B
ERLIN2 ER lipid raft associated 2
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FOXC1 forkhead box C1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
IGFBP6 insulin-like growth factor binding protein 6
MAT2A methionine adenosyltransferase II, alpha
MFAP5 microfibrillar associated protein 5
MYH11 myosin, heavy chain 11, smooth muscle
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NLRP2 NLR family, pyrin domain containing 2
NOP56 NOP56 ribonucleoprotein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SRSF7 serine/arginine-rich splicing factor 7
TLR4 toll-like receptor 4