BRD-A68061604_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-A68061604_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
CCL5 chemokine (C-C motif) ligand 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CTSK cathepsin K
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DES desmin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FAP fibroblast activation protein, alpha
FCGBP Fc fragment of IgG binding protein
FILIP1L filamin A interacting protein 1-like
FOXO3 forkhead box O3
FXYD5 FXYD domain containing ion transport regulator 5
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSR insulin receptor
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
MYH11 myosin, heavy chain 11, smooth muscle
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PDZK1IP1 PDZK1 interacting protein 1
PLIN2 perilipin 2
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAP1GAP RAP1 GTPase activating protein
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQLE squalene epoxidase
STC1 stanniocalcin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DCK deoxycytidine kinase
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1L dynamin 1-like
EBNA1BP2 EBNA1 binding protein 2
EED embryonic ectoderm development
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FANCI Fanconi anemia, complementation group I
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMFB glia maturation factor, beta
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HLF hepatic leukemia factor
HOXC6 homeobox C6
HRSP12 heat-responsive protein 12
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MRPL15 mitochondrial ribosomal protein L15
NBN nibrin
NDC1 NDC1 transmembrane nucleoporin
NEK2 NIMA-related kinase 2
NPY neuropeptide Y
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB40B RAB40B, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RRP1B ribosomal RNA processing 1B
SERBP1 SERPINE1 mRNA binding protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TMEM70 transmembrane protein 70
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
XPO1 exportin 1
XPO7 exportin 7
ZWINT ZW10 interacting kinetochore protein