BRD-A68061604_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A68061604_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLC Charcot-Leyden crystal galectin
COBL cordon-bleu WH2 repeat protein
COL11A1 collagen, type XI, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
EBP emopamil binding protein (sterol isomerase)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS1 growth arrest-specific 1
GOLGA8H golgin A8 family, member H
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KLHDC8A kelch domain containing 8A
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MSMO1 methylsterol monooxygenase 1
MYO1D myosin ID
NID2 nidogen 2 (osteonidogen)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLXNC1 plexin C1
PNPLA3 patatin-like phospholipase domain containing 3
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RPL37A ribosomal protein L37a
SARAF store-operated calcium entry-associated regulatory factor
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SOX2 SRY (sex determining region Y)-box 2
TIMP2 TIMP metallopeptidase inhibitor 2
USP6NL USP6 N-terminal like
WFDC1 WAP four-disulfide core domain 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCL19 chemokine (C-C motif) ligand 19
CD59 CD59 molecule, complement regulatory protein
CNN3 calponin 3, acidic
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FBXO21 F-box protein 21
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTP1 glutathione S-transferase pi 1
GTPBP8 GTP-binding protein 8 (putative)
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ISOC1 isochorismatase domain containing 1
KANK1 KN motif and ankyrin repeat domains 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
NNMT nicotinamide N-methyltransferase
PAX5 paired box 5
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RGS13 regulator of G-protein signaling 13
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOD2 superoxide dismutase 2, mitochondrial
SRSF6 serine/arginine-rich splicing factor 6
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91