BRD-A68009927_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-A68009927_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARL4C ADP-ribosylation factor-like 4C
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA1 cyclin A1
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CTSZ cathepsin Z
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTRA1 HtrA serine peptidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KIAA1462 KIAA1462
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MXRA7 matrix-remodelling associated 7
NTS neurotensin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECR peroxisomal trans-2-enoyl-CoA reductase
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG3A regenerating islet-derived 3 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SST somatostatin
STC1 stanniocalcin 1
TCTN1 tectonic family member 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VNN1 vanin 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADNP activity-dependent neuroprotector homeobox
AGR2 anterior gradient 2
AP5M1 adaptor-related protein complex 5, mu 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMT1 acidic residue methyltransferase 1
ASF1A anti-silencing function 1A histone chaperone
ASNSD1 asparagine synthetase domain containing 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL12 chemokine (C-X-C motif) ligand 12
DCLK1 doublecortin-like kinase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOXA1 forkhead box A1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GEMIN4 gem (nuclear organelle) associated protein 4
GLOD4 glyoxalase domain containing 4
GOSR1 golgi SNAP receptor complex member 1
GTPBP4 GTP binding protein 4
HEATR1 HEAT repeat containing 1
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KIAA0101 KIAA0101
KIF5B kinesin family member 5B
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LDLRAD4 low density lipoprotein receptor class A domain containing 4
MAX MYC associated factor X
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MOB4 MOB family member 4, phocein
MREG melanoregulin
MSMB microseminoprotein, beta-
MTPAP mitochondrial poly(A) polymerase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRC1 protein regulator of cytokinesis 1
PRPF4B pre-mRNA processing factor 4B
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RAB14 RAB14, member RAS oncogene family
RANBP2 RAN binding protein 2
RNF139 ring finger protein 139
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SFPQ splicing factor proline/glutamine-rich
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBP TATA box binding protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPD52L1 tumor protein D52-like 1
TRAPPC3 trafficking protein particle complex 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
VCPKMT valosin containing protein lysine (K) methyltransferase
XBP1 X-box binding protein 1
ZMYM2 zinc finger, MYM-type 2
ZNF146 zinc finger protein 146