BRD-A68009927_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-A68009927_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOR1 adiponectin receptor 1
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CD47 CD47 molecule
CD99 CD99 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CNR1 cannabinoid receptor 1 (brain)
CTSZ cathepsin Z
CYBA cytochrome b-245, alpha polypeptide
DHCR24 24-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
EMP1 epithelial membrane protein 1
ENDOD1 endonuclease domain containing 1
ENO1 enolase 1, (alpha)
FTO fat mass and obesity associated
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPM6A glycoprotein M6A
GUK1 guanylate kinase 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
LAGE3 L antigen family, member 3
LEF1 lymphoid enhancer-binding factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARCO macrophage receptor with collagenous structure
MFSD1 major facilitator superfamily domain containing 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPP1 membrane protein, palmitoylated 1, 55kDa
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEBL nebulette
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OAT ornithine aminotransferase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PFKM phosphofructokinase, muscle
PLS3 plastin 3
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PON2 paraoxonase 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPT1 palmitoyl-protein thioesterase 1
PRDX2 peroxiredoxin 2
PROS1 protein S (alpha)
PSENEN presenilin enhancer gamma secretase subunit
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RAB4A RAB4A, member RAS oncogene family
RASA4 RAS p21 protein activator 4
S100A10 S100 calcium binding protein A10
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SKAP2 src kinase associated phosphoprotein 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORD sorbitol dehydrogenase
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSBP2 single-stranded DNA binding protein 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TUSC3 tumor suppressor candidate 3
UNC13B unc-13 homolog B (C. elegans)
VAMP3 vesicle-associated membrane protein 3
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4A ADP-ribosylation factor-like 4A
BASP1 brain abundant, membrane attached signal protein 1
BCL10 B-cell CLL/lymphoma 10
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHIC2 cysteine-rich hydrophobic domain 2
CST7 cystatin F (leukocystatin)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KIF2A kinesin heavy chain member 2A
KIZ kizuna centrosomal protein
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LIPT1 lipoyltransferase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OSER1 oxidative stress responsive serine-rich 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
PWP1 PWP1 homolog (S. cerevisiae)
RHOF ras homolog family member F (in filopodia)
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
STIL SCL/TAL1 interrupting locus
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZFP36L2 ZFP36 ring finger protein-like 2