BRD-A68009927_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

348 genes differentially expressed following the BRD-A68009927_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAG6 BCL2-associated athanogene 6
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EML1 echinoderm microtubule associated protein like 1
ESRP1 epithelial splicing regulatory protein 1
FAM134B family with sequence similarity 134, member B
FLT1 fms-related tyrosine kinase 1
FOXF1 forkhead box F1
GAS6 growth arrest-specific 6
GLO1 glyoxalase I
GPM6A glycoprotein M6A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1462 KIAA1462
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MAOA monoamine oxidase A
MBOAT2 membrane bound O-acyltransferase domain containing 2
MT1F metallothionein 1F
NEBL nebulette
NRP1 neuropilin 1
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRSS16 protease, serine, 16 (thymus)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
PTTG1IP pituitary tumor-transforming 1 interacting protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3YL1 SH3 and SYLF domain containing 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TNS1 tensin 1
TSPAN7 tetraspanin 7
UGP2 UDP-glucose pyrophosphorylase 2
VASH1 vasohibin 1
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ARHGAP12 Rho GTPase activating protein 12
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CAPN6 calpain 6
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COCH cochlin
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DFNA5 deafness, autosomal dominant 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EED embryonic ectoderm development
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
EXOSC4 exosome component 4
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FAM53C family with sequence similarity 53, member C
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST3H2A histone cluster 3, H2a
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HSF2 heat shock transcription factor 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MID1 midline 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTF2 metal response element binding transcription factor 2
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PHF20 PHD finger protein 20
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMP22 peripheral myelin protein 22
PNISR PNN-interacting serine/arginine-rich protein
PNMA1 paraneoplastic Ma antigen 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIF peptidylprolyl isomerase F
PRDM2 PR domain containing 2, with ZNF domain
PRKCA protein kinase C, alpha
PTHLH parathyroid hormone-like hormone
PTRH2 peptidyl-tRNA hydrolase 2
PTX3 pentraxin 3, long
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RBM7 RNA binding motif protein 7
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RIN2 Ras and Rab interactor 2
RIT1 Ras-like without CAAX 1
RNF111 ring finger protein 111
RNF19B ring finger protein 19B
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RUNX3 runt-related transcription factor 3
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC24A SEC24 family member A
SECISBP2L SECIS binding protein 2-like
SEPHS2 selenophosphate synthetase 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SF1 splicing factor 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRSF11 serine/arginine-rich splicing factor 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VEZF1 vascular endothelial zinc finger 1
WAC WW domain containing adaptor with coiled-coil
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF131 zinc finger protein 131
ZNF263 zinc finger protein 263
ZNF267 zinc finger protein 267
ZNF330 zinc finger protein 330