BRD-A67799922_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A67799922_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
BLVRB biliverdin reductase B
C14ORF132 chromosome 14 open reading frame 132
CD163 CD163 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CTSB cathepsin B
CTSK cathepsin K
CTSL cathepsin L
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IGFBP6 insulin-like growth factor binding protein 6
ISLR immunoglobulin superfamily containing leucine-rich repeat
LGALS8 lectin, galactoside-binding, soluble, 8
LTF lactotransferrin
LY96 lymphocyte antigen 96
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYB v-myb avian myeloblastosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PTER phosphotriesterase related
PTPRE protein tyrosine phosphatase, receptor type, E
RABGAP1L RAB GTPase activating protein 1-like
RPS27L ribosomal protein S27-like
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
STAB1 stabilin 1
STEAP3 STEAP family member 3, metalloreductase
TMEM176B transmembrane protein 176B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TRBC1 T cell receptor beta constant 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGTR1 angiotensin II receptor, type 1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ATM ATM serine/threonine kinase
BPHL biphenyl hydrolase-like (serine hydrolase)
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COL15A1 collagen, type XV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL4A6 collagen, type IV, alpha 6
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DKK3 dickkopf WNT signaling pathway inhibitor 3
DVL1 dishevelled segment polarity protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPHA3 EPH receptor A3
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB14 growth factor receptor-bound protein 14
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MECOM MDS1 and EVI1 complex locus
MID1 midline 1
MMD monocyte to macrophage differentiation-associated
MYRF myelin regulatory factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NTS neurotensin
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PPAP2A phosphatidic acid phosphatase type 2A
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
UBE2C ubiquitin-conjugating enzyme E2C
WNT5A wingless-type MMTV integration site family, member 5A