BRD-A66559694_NALTREXONE HYDROCHLORIDE_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-A66559694_NALTREXONE HYDROCHLORIDE_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AMOTL2 angiomotin like 2
ANXA4 annexin A4
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CD40 CD40 molecule, TNF receptor superfamily member 5
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CLEC3B C-type lectin domain family 3, member B
CLIC5 chloride intracellular channel 5
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
ERLIN2 ER lipid raft associated 2
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
GSTA1 glutathione S-transferase alpha 1
HBD hemoglobin, delta
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R1 interleukin 1 receptor, type I
MXI1 MAX interactor 1, dimerization protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPTX2 neuronal pentraxin II
PEG10 paternally expressed 10
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANXA7 annexin A7
CA12 carbonic anhydrase XII
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6ST interleukin 6 signal transducer
ITM2A integral membrane protein 2A
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
MACF1 microtubule-actin crosslinking factor 1
MMP1 matrix metallopeptidase 1
PCDH9 protocadherin 9
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPRR2B small proline-rich protein 2B
THAP11 THAP domain containing 11
TSPYL5 TSPY-like 5