BRD-A64290322_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-A64290322_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BET1 Bet1 golgi vesicular membrane trafficking protein
BHLHE41 basic helix-loop-helix family, member e41
CA1 carbonic anhydrase I
CALU calumenin
CCND2 cyclin D2
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLCN4 chloride channel, voltage-sensitive 4
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAD1 defender against cell death 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DHDDS dehydrodolichyl diphosphate synthase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
ERP44 endoplasmic reticulum protein 44
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GMPPA GDP-mannose pyrophosphorylase A
GOLGA2 golgin A2
GOLPH3L golgi phosphoprotein 3-like
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRB10 growth factor receptor-bound protein 10
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
ICAM2 intercellular adhesion molecule 2
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHA1 immunoglobulin heavy constant alpha 1
INSIG1 insulin induced gene 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPG lipase, endothelial
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MANF mesencephalic astrocyte-derived neurotrophic factor
MPO myeloperoxidase
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANS N-acetylneuraminic acid synthase
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGM3 phosphoglucomutase 3
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
RRBP1 ribosome binding protein 1
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEC13 SEC13 homolog (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SEC61B Sec61 beta subunit
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A10 solute carrier family 38, member 10
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SSR1 signal sequence receptor, alpha
STC2 stanniocalcin 2
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TES testin LIM domain protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM100 transmembrane protein 100
TMEM214 transmembrane protein 214
TMEM39A transmembrane protein 39A
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
USO1 USO1 vesicle transport factor
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATF5 activating transcription factor 5
C7 complement component 7
CCND1 cyclin D1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CTSH cathepsin H
DLK1 delta-like 1 homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
GATA2 GATA binding protein 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP7 insulin-like growth factor binding protein 7
LAPTM4B lysosomal protein transmembrane 4 beta
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
PFKP phosphofructokinase, platelet
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXNA1 plexin A1
PODXL podocalyxin-like
PRRC2C proline-rich coiled-coil 2C
RPP38 ribonuclease P/MRP 38kDa subunit
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
STMN1 stathmin 1
TBC1D4 TBC1 domain family, member 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBB2A tubulin, beta 2A class IIa
ZWINT ZW10 interacting kinetochore protein