BRD-A64290322_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A64290322_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
C9ORF3 chromosome 9 open reading frame 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP14 dual specificity phosphatase 14
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KIAA0753 KIAA0753
LARP6 La ribonucleoprotein domain family, member 6
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIS12 MIS12 kinetochore complex component
MME membrane metallo-endopeptidase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
P4HB prolyl 4-hydroxylase, beta polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PHLDA3 pleckstrin homology-like domain, family A, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SESN1 sestrin 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM22 tripartite motif containing 22
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT23 keratin 23, type I
MARCKSL1 MARCKS-like 1
MKI67 marker of proliferation Ki-67
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PTTG1 pituitary tumor-transforming 1
RBP1 retinol binding protein 1, cellular
SORBS2 sorbin and SH3 domain containing 2
SPC25 SPC25, NDC80 kinetochore complex component
SRI sorcin
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C