BRD-A62336480_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A62336480_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
COL1A1 collagen, type I, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ETV5 ets variant 5
EVI2A ecotropic viral integration site 2A
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
LCN2 lipocalin 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
SARS seryl-tRNA synthetase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP1 TIMP metallopeptidase inhibitor 1
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
UFM1 ubiquitin-fold modifier 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
B3GNT1
CCNF cyclin F
CKB creatine kinase, brain
COL3A1 collagen, type III, alpha 1
DMD dystrophin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLRT3 fibronectin leucine rich transmembrane protein 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF20A kinesin family member 20A
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MET MET proto-oncogene, receptor tyrosine kinase
MYCBP MYC binding protein
PBX3 pre-B-cell leukemia homeobox 3
PDZK1 PDZ domain containing 1
PGK1 phosphoglycerate kinase 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PODXL podocalyxin-like
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXMP2 peroxisomal membrane protein 2, 22kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPM1 tropomyosin 1 (alpha)