BRD-A62326914_paroxetine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-A62326914_paroxetine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BLNK B-cell linker
CD9 CD9 molecule
CXCL10 chemokine (C-X-C motif) ligand 10
FBN2 fibrillin 2
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GPER1 G protein-coupled estrogen receptor 1
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
LYPD1 LY6/PLAUR domain containing 1
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
PCP4 Purkinje cell protein 4
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SQLE squalene epoxidase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETNK1 ethanolamine kinase 1
F3 coagulation factor III (thromboplastin, tissue factor)
GCLM glutamate-cysteine ligase, modifier subunit
GMDS GDP-mannose 4,6-dehydratase
GRIA2 glutamate receptor, ionotropic, AMPA 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM5 PDZ and LIM domain 5
PEBP1 phosphatidylethanolamine binding protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
QDPR quinoid dihydropteridine reductase
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)