BRD-A62184259_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A62184259_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CHD9 chromodomain helicase DNA binding protein 9
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
CLTB clathrin, light chain B
CNR1 cannabinoid receptor 1 (brain)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLX2 distal-less homeobox 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELN elastin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
FLRT3 fibronectin leucine rich transmembrane protein 3
FNDC3B fibronectin type III domain containing 3B
FZD5 frizzled class receptor 5
GADD45B growth arrest and DNA-damage-inducible, beta
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LDHB lactate dehydrogenase B
LIMA1 LIM domain and actin binding 1
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
NEBL nebulette
PCDH9 protocadherin 9
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDE4D phosphodiesterase 4D, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PPAT phosphoribosyl pyrophosphate amidotransferase
QKI QKI, KH domain containing, RNA binding
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SCYL3 SCY1-like 3 (S. cerevisiae)
SIK1 salt-inducible kinase 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC35F2 solute carrier family 35, member F2
STK38L serine/threonine kinase 38 like
TGM2 transglutaminase 2
THBD thrombomodulin
TLK2 tousled-like kinase 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
YTHDC1 YTH domain containing 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
B3GNT1
BAG3 BCL2-associated athanogene 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CRYZ crystallin, zeta (quinone reductase)
CSK c-src tyrosine kinase
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DCTPP1 dCTP pyrophosphatase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ESR1 estrogen receptor 1
ESYT1 extended synaptotagmin-like protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G6PD glucose-6-phosphate dehydrogenase
GRN granulin
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL17RB interleukin 17 receptor B
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
MAGED2 melanoma antigen family D2
MDK midkine (neurite growth-promoting factor 2)
METTL3 methyltransferase like 3
MSMO1 methylsterol monooxygenase 1
MTMR4 myotubularin related protein 4
NHP2 NHP2 ribonucleoprotein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUPR1 nuclear protein, transcriptional regulator, 1
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRSS23 protease, serine, 23
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB31 RAB31, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS11 ribosomal protein S11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SPDEF SAM pointed domain containing ETS transcription factor
SQLE squalene epoxidase
STMN1 stathmin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TPBG trophoblast glycoprotein
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TWF2 twinfilin actin binding protein 2
WDTC1 WD and tetratricopeptide repeats 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA