BRD-A62184259_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-A62184259_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCOR BCL6 corepressor
BRD4 bromodomain containing 4
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CDC25A cell division cycle 25A
CDKN2AIP CDKN2A interacting protein
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CPM carboxypeptidase M
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
ELF4 E74-like factor 4 (ets domain transcription factor)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
PARM1 prostate androgen-regulated mucin-like protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLVAP plasmalemma vesicle associated protein
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QKI QKI, KH domain containing, RNA binding
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
SDC4 syndecan 4
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPEN spen family transcriptional repressor
TERF2IP telomeric repeat binding factor 2, interacting protein
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADA adenosine deaminase
ADRB2 adrenoceptor beta 2, surface
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
ENO2 enolase 2 (gamma, neuronal)
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLA galactosidase, alpha
GMDS GDP-mannose 4,6-dehydratase
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL17RB interleukin 17 receptor B
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP2K6 mitogen-activated protein kinase kinase 6
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAT2A methionine adenosyltransferase II, alpha
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOV nephroblastoma overexpressed
NQO1 NAD(P)H dehydrogenase, quinone 1
OXA1L oxidase (cytochrome c) assembly 1-like
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PROM1 prominin 1
RAP2A RAP2A, member of RAS oncogene family
RELN reelin
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNN stannin
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TSPYL5 TSPY-like 5
URI1 URI1, prefoldin-like chaperone
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1