BRD-A62025033_temsirolimus [CI779]_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-A62025033_temsirolimus [CI779]_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ANKRD36B ankyrin repeat domain 36B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
C10ORF10 chromosome 10 open reading frame 10
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CLEC2B C-type lectin domain family 2, member B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DSP desmoplakin
EFHD1 EF-hand domain family, member D1
ENO1 enolase 1, (alpha)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGFR2 fibroblast growth factor receptor 2
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GRN granulin
HEBP2 heme binding protein 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MAP3K7CL MAP3K7 C-terminal like
MICALL1 MICAL-like 1
MMP9 matrix metallopeptidase 9
MYO6 myosin VI
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PON3 paraoxonase 3
RAD51AP1 RAD51 associated protein 1
SDC2 syndecan 2
SDC4 syndecan 4
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX10 sorting nexin 10
SYBU syntabulin (syntaxin-interacting)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
VNN1 vanin 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADD3 adducin 3 (gamma)
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AURKA aurora kinase A
BIN1 bridging integrator 1
CA12 carbonic anhydrase XII
CDC20 cell division cycle 20
CDH19 cadherin 19, type 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHL1 cell adhesion molecule L1-like
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPM6B glycoprotein M6B
HMBS hydroxymethylbilane synthase
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IPO13 importin 13
LXN latexin
MAGEA3 melanoma antigen family A3
MBOAT2 membrane bound O-acyltransferase domain containing 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPY neuropeptide Y
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PLK2 polo-like kinase 2
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUBA4A tubulin, alpha 4a
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon