BRD-A62025033_temsirolimus [CI779]_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-A62025033_temsirolimus [CI779]_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
ANO1 anoctamin 1, calcium activated chloride channel
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLDN3 claudin 3
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EDN3 endothelin 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ETV5 ets variant 5
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
FZD10 frizzled class receptor 10
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA4 golgin A4
GSE1 Gse1 coiled-coil protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KLHDC2 kelch domain containing 2
KRT23 keratin 23, type I
LDOC1 leucine zipper, down-regulated in cancer 1
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG10 paternally expressed 10
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PSAP prosaposin
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SULF1 sulfatase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
AURKA aurora kinase A
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CTR9 CTR9, Paf1/RNA polymerase II complex component
DDIT4 DNA-damage-inducible transcript 4
EED embryonic ectoderm development
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FASTKD5 FAST kinase domains 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPB8 heat shock 22kDa protein 8
KRT10 keratin 10, type I
MIR22HG MIR22 host gene
MRPS30 mitochondrial ribosomal protein S30
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NUP98 nucleoporin 98kDa
PCTP phosphatidylcholine transfer protein
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RBM12 RNA binding motif protein 12
RPP38 ribonuclease P/MRP 38kDa subunit
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRP1B ribosomal RNA processing 1B
S100A10 S100 calcium binding protein A10
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFPQ splicing factor proline/glutamine-rich
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST7 suppression of tumorigenicity 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TESC tescalcin
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM164 transmembrane protein 164
TMPO thymopoietin
TRA2B transformer 2 beta homolog (Drosophila)
UBE2E1 ubiquitin-conjugating enzyme E2E 1
ZMYM2 zinc finger, MYM-type 2