BRD-A61825514_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A61825514_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CD69 CD69 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CKB creatine kinase, brain
CRYAB crystallin, alpha B
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DENND5A DENN/MADD domain containing 5A
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP2 dual specificity phosphatase 2
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
FAM162A family with sequence similarity 162, member A
FAM57A family with sequence similarity 57, member A
FOSL2 FOS-like antigen 2
GYS1 glycogen synthase 1 (muscle)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0125 KIAA0125
KIF5C kinesin family member 5C
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFE2 nuclear factor, erythroid 2
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
NOTCH1 notch 1
NRN1 neuritin 1
NXN nucleoredoxin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDHX pyruvate dehydrogenase complex, component X
PDLIM2 PDZ and LIM domain 2 (mystique)
PECAM1 platelet/endothelial cell adhesion molecule 1
PGK1 phosphoglycerate kinase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLTP phospholipid transfer protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBKS ribokinase
RNMT RNA (guanine-7-) methyltransferase
RORA RAR-related orphan receptor A
RPL39L ribosomal protein L39-like
RRAGD Ras-related GTP binding D
S100A14 S100 calcium binding protein A14
SCGB2A2 secretoglobin, family 2A, member 2
SERTAD2 SERTA domain containing 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMYD3 SET and MYND domain containing 3
SPAG4 sperm associated antigen 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC2 stanniocalcin 2
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF4 transcription factor 4
TGM2 transglutaminase 2
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOB aldolase B, fructose-bisphosphate
ANXA1 annexin A1
ANXA2 annexin A2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
CD24 CD24 molecule
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
EPCAM epithelial cell adhesion molecule
EPS8 epidermal growth factor receptor pathway substrate 8
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GSDMB gasdermin B
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
KIF14 kinesin family member 14
KYNU kynureninase
MGP matrix Gla protein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPBG trophoblast glycoprotein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)