BRD-A60414806_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-A60414806_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
AMDHD2 amidohydrolase domain containing 2
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BHLHE40 basic helix-loop-helix family, member e40
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CORO1C coronin, actin binding protein, 1C
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EGR3 early growth response 3
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
IL18 interleukin 18
JUND jun D proto-oncogene
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MAST2 microtubule associated serine/threonine kinase 2
NNMT nicotinamide N-methyltransferase
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMEPA1 prostate transmembrane protein, androgen induced 1
RHOB ras homolog family member B
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TPM4 tropomyosin 4
TSC22D2 TSC22 domain family, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA1A tubulin, alpha 1a
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
ZNF586 zinc finger protein 586
ZYX zyxin

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
CADPS2 Ca++-dependent secretion activator 2
CCDC86 coiled-coil domain containing 86
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHN2 chimerin 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRYL1 crystallin, lambda 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DMD dystrophin
DUSP6 dual specificity phosphatase 6
FLT1 fms-related tyrosine kinase 1
FZD4 frizzled class receptor 4
GJA1 gap junction protein, alpha 1, 43kDa
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXC10 homeobox C10
IFITM1 interferon induced transmembrane protein 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LDHB lactate dehydrogenase B
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MFAP3L microfibrillar-associated protein 3-like
MME membrane metallo-endopeptidase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PKP4 plakophilin 4
PNMAL1 paraneoplastic Ma antigen family-like 1
POSTN periostin, osteoblast specific factor
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SERINC5 serine incorporator 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon