BRD-A60245366_AS-601245_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A60245366_AS-601245_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP11B ATPase, class VI, type 11B
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCHE butyrylcholinesterase
BTN3A2 butyrophilin, subfamily 3, member A2
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPG capping protein (actin filament), gelsolin-like
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD84 CD84 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
ECI2 enoyl-CoA delta isomerase 2
ELOVL5 ELOVL fatty acid elongase 5
ENO2 enolase 2 (gamma, neuronal)
FLOT1 flotillin 1
GLO1 glyoxalase I
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GSTT1 glutathione S-transferase theta 1
HIST3H2A histone cluster 3, H2a
HOPX HOP homeobox
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LIF leukemia inhibitory factor
LYPD1 LY6/PLAUR domain containing 1
MAOB monoamine oxidase B
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLEC malectin
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
NMU neuromedin U
NT5DC2 5'-nucleotidase domain containing 2
PDIA6 protein disulfide isomerase family A, member 6
PLAT plasminogen activator, tissue
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRAME preferentially expressed antigen in melanoma
QPCT glutaminyl-peptide cyclotransferase
RAD51C RAD51 paralog C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS2 regulator of G-protein signaling 2
SF1 splicing factor 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLN sarcolipin
SORT1 sortilin 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
TFRC transferrin receptor
TMOD1 tropomodulin 1
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
APOLD1 apolipoprotein L domain containing 1
ARMCX1 armadillo repeat containing, X-linked 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CALB1 calbindin 1, 28kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNB1 cyclin B1
CCNF cyclin F
CD24 CD24 molecule
CD93 CD93 molecule
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDV3 CDV3 homolog (mouse)
CFD complement factor D (adipsin)
CHD7 chromodomain helicase DNA binding protein 7
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELMO1 engulfment and cell motility 1
FHL2 four and a half LIM domains 2
FSCN1 fascin actin-bundling protein 1
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KMT2A lysine (K)-specific methyltransferase 2A
KYNU kynureninase
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MID1IP1 MID1 interacting protein 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MYH11 myosin, heavy chain 11, smooth muscle
NPY1R neuropeptide Y receptor Y1
OLFM1 olfactomedin 1
OLFML2B olfactomedin-like 2B
PFDN4 prefoldin subunit 4
PHYH phytanoyl-CoA 2-hydroxylase
PLK1 polo-like kinase 1
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
PPAP2A phosphatidic acid phosphatase type 2A
PSCA prostate stem cell antigen
PTK6 protein tyrosine kinase 6
RGS5 regulator of G-protein signaling 5
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SEPHS1 selenophosphate synthetase 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
TARP TCR gamma alternate reading frame protein
TBC1D31 TBC1 domain family, member 31
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TNS3 tensin 3
TPBG trophoblast glycoprotein
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
ZHX2 zinc fingers and homeoboxes 2
ZNF165 zinc finger protein 165