BRD-A60245366_AS-601245_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A60245366_AS-601245_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASRGL1 asparaginase like 1
CA12 carbonic anhydrase XII
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CEMIP cell migration inducing protein, hyaluronan binding
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ENO1 enolase 1, (alpha)
FOLR1 folate receptor 1 (adult)
GPER1 G protein-coupled estrogen receptor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOOK2 hook microtubule-tethering protein 2
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KYNU kynureninase
LTF lactotransferrin
MPPED2 metallophosphoesterase domain containing 2
MSX1 msh homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFML2A olfactomedin-like 2A
PITX1 paired-like homeodomain 1
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SST somatostatin
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VIM vimentin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
BACE2 beta-site APP-cleaving enzyme 2
BCHE butyrylcholinesterase
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLIC5 chloride intracellular channel 5
COL14A1 collagen, type XIV, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST7 cystatin F (leukocystatin)
CTSW cathepsin W
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
GDF15 growth differentiation factor 15
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GREM1 gremlin 1, DAN family BMP antagonist
GZMK granzyme K (granzyme 3; tryptase II)
HSPA2 heat shock 70kDa protein 2
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
MMP9 matrix metallopeptidase 9
MRPS30 mitochondrial ribosomal protein S30
MTSS1 metastasis suppressor 1
MYLK myosin light chain kinase
NT5E 5'-nucleotidase, ecto (CD73)
PDLIM5 PDZ and LIM domain 5
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SPP1 secreted phosphoprotein 1
STK39 serine threonine kinase 39
SULF1 sulfatase 1
TOB1 transducer of ERBB2, 1
ZBTB16 zinc finger and BTB domain containing 16
ZNF281 zinc finger protein 281