BRD-A60245366_AS-601245_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-A60245366_AS-601245_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BCL2A1 BCL2-related protein A1
BECN1 beclin 1, autophagy related
CA12 carbonic anhydrase XII
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL14 chemokine (C-X-C motif) ligand 14
EML3 echinoderm microtubule associated protein like 3
ENO2 enolase 2 (gamma, neuronal)
FAM63A family with sequence similarity 63, member A
FASTKD5 FAST kinase domains 5
GC group-specific component (vitamin D binding protein)
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GRB14 growth factor receptor-bound protein 14
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KLK11 kallikrein-related peptidase 11
MCOLN1 mucolipin 1
PCP4 Purkinje cell protein 4
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PREPL prolyl endopeptidase-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RHOQ ras homolog family member Q
S100A8 S100 calcium binding protein A8
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNX11 sorting nexin 11
SOD2 superoxide dismutase 2, mitochondrial
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TWF1 twinfilin actin binding protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATM ATM serine/threonine kinase
AUTS2 autism susceptibility candidate 2
BGN biglycan
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CCNF cyclin F
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CH25H cholesterol 25-hydroxylase
CHD7 chromodomain helicase DNA binding protein 7
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
ECM1 extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
ERBB2 erb-b2 receptor tyrosine kinase 2
FZD7 frizzled class receptor 7
GPX2 glutathione peroxidase 2
HEPH hephaestin
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
KDM3A lysine (K)-specific demethylase 3A
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LPAR6 lysophosphatidic acid receptor 6
MMP11 matrix metallopeptidase 11
MYH10 myosin, heavy chain 10, non-muscle
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDE4D phosphodiesterase 4D, cAMP-specific
PHF20 PHD finger protein 20
PLAC8 placenta-specific 8
PTPRO protein tyrosine phosphatase, receptor type, O
RIN2 Ras and Rab interactor 2
RNF167 ring finger protein 167
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TGIF1 TGFB-induced factor homeobox 1
VCAN versican
XBP1 X-box binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF652 zinc finger protein 652