BRD-A60245366_AS-601245_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A60245366_AS-601245_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BPGM 2,3-bisphosphoglycerate mutase
CA12 carbonic anhydrase XII
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD248 CD248 molecule, endosialin
CD48 CD48 molecule
CERK ceramide kinase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHODL chondrolectin
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
DEFB1 defensin, beta 1
EGR2 early growth response 2
FAM3C family with sequence similarity 3, member C
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCMR Fc fragment of IgM receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP11 FK506 binding protein 11, 19 kDa
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
FXYD6 FXYD domain containing ion transport regulator 6
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GNLY granulysin
GSTA4 glutathione S-transferase alpha 4
GYPC glycophorin C (Gerbich blood group)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHA1 immunoglobulin heavy constant alpha 1
IGHD immunoglobulin heavy constant delta
IL2RB interleukin 2 receptor, beta
IL32 interleukin 32
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBH limb bud and heart development
LSP1 lymphocyte-specific protein 1
LSR lipolysis stimulated lipoprotein receptor
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MREG melanoregulin
NES nestin
NUP210 nucleoporin 210kDa
NXT2 nuclear transport factor 2-like export factor 2
PRF1 perforin 1 (pore forming protein)
PRR5 proline rich 5 (renal)
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RORA RAR-related orphan receptor A
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SFTPB surfactant protein B
SLAMF1 signaling lymphocytic activation molecule family member 1
SPRR1B small proline-rich protein 1B
STK26 serine/threonine protein kinase 26
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPST2 tyrosylprotein sulfotransferase 2
TRAC T cell receptor alpha constant
VEGFA vascular endothelial growth factor A
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
AXL AXL receptor tyrosine kinase
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
CAB39 calcium binding protein 39
CCP110 centriolar coiled coil protein 110kDa
CD9 CD9 molecule
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSZ cathepsin Z
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP3 dual specificity phosphatase 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR2 fibroblast growth factor receptor 2
FKBP5 FK506 binding protein 5
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLIPR1 GLI pathogenesis-related 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HIST1H2BG histone cluster 1, H2bg
HSPH1 heat shock 105kDa/110kDa protein 1
HTRA1 HtrA serine peptidase 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
KIF1BP KIF1 binding protein
LOXL2 lysyl oxidase-like 2
LXN latexin
LYZ lysozyme
MBNL1 muscleblind-like splicing regulator 1
MT1M metallothionein 1M
MTUS1 microtubule associated tumor suppressor 1
NET1 neuroepithelial cell transforming 1
NGRN neugrin, neurite outgrowth associated
NKTR natural killer cell triggering receptor
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
NUP93 nucleoporin 93kDa
PLN phospholamban
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA4 RAS p21 protein activator 4
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SERINC3 serine incorporator 3
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRRM2 serine/arginine repetitive matrix 2
STAU1 staufen double-stranded RNA binding protein 1
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THBS1 thrombospondin 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
VANGL1 VANGL planar cell polarity protein 1
VWF von Willebrand factor
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB16 zinc finger and BTB domain containing 16
ZNF423 zinc finger protein 423