BRD-A60245366_AS-601245_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-A60245366_AS-601245_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CLEC2B C-type lectin domain family 2, member B
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ENO2 enolase 2 (gamma, neuronal)
FCGBP Fc fragment of IgG binding protein
GADD45A growth arrest and DNA-damage-inducible, alpha
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
JUND jun D proto-oncogene
KLK5 kallikrein-related peptidase 5
LGALS8 lectin, galactoside-binding, soluble, 8
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP1 matrix metallopeptidase 1
NEFL neurofilament, light polypeptide
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDHX pyruvate dehydrogenase complex, component X
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RORA RAR-related orphan receptor A
SALL1 spalt-like transcription factor 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX17 SRY (sex determining region Y)-box 17
STAB1 stabilin 1
STXBP6 syntaxin binding protein 6 (amisyn)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
ARMCX2 armadillo repeat containing, X-linked 2
BCAS1 breast carcinoma amplified sequence 1
C6ORF62 chromosome 6 open reading frame 62
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
DCN decorin
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FBN1 fibrillin 1
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
GPSM2 G-protein signaling modulator 2
GSTP1 glutathione S-transferase pi 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KYNU kynureninase
LTBP1 latent transforming growth factor beta binding protein 1
LY75 lymphocyte antigen 75
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
MSRB2 methionine sulfoxide reductase B2
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPCT glutaminyl-peptide cyclotransferase
RBKS ribokinase
RPL37A ribosomal protein L37a
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TF transferrin
VCAN versican