BRD-A60245366_-666_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-A60245366_-666_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
AQP1 aquaporin 1 (Colton blood group)
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CANX calnexin
CD24 CD24 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLGN calmegin
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
DAD1 defender against cell death 1
DHCR24 24-dehydrocholesterol reductase
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
F11R F11 receptor
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLO1 glyoxalase I
GPX3 glutathione peroxidase 3
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LTB lymphotoxin beta (TNF superfamily, member 3)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MT1E metallothionein 1E
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPTX2 neuronal pentraxin II
NTS neurotensin
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PFN2 profilin 2
PRKCI protein kinase C, iota
PSENEN presenilin enhancer gamma secretase subunit
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
SDC2 syndecan 2
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPB surfactant protein B
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SPON1 spondin 1, extracellular matrix protein
TAGLN transgelin
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TMEM259 transmembrane protein 259
TMSB15A thymosin beta 15a
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
C1S complement component 1, s subcomponent
CAPN6 calpain 6
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN2AIP CDKN2A interacting protein
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHD1 chromodomain helicase DNA binding protein 1
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CRTC3 CREB regulated transcription coactivator 3
CTPS1 CTP synthase 1
CTSW cathepsin W
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EHD1 EH-domain containing 1
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM193A family with sequence similarity 193, member A
FAM222B family with sequence similarity 222, member B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS2 mitochondrial ribosomal protein S2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NET1 neuroepithelial cell transforming 1
NPAT nuclear protein, ataxia-telangiectasia locus
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRF1 perforin 1 (pore forming protein)
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RANBP2 RAN binding protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RREB1 ras responsive element binding protein 1
RRP1B ribosomal RNA processing 1B
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SEC24A SEC24 family member A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SNUPN snurportin 1
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TBP TATA box binding protein
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE3 transducin-like enhancer of split 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UBE3A ubiquitin protein ligase E3A
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF185 zinc finger protein 185 (LIM domain)
ZYX zyxin