BRD-A60245366_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

345 genes differentially expressed following the BRD-A60245366_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD17A abhydrolase domain containing 17A
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACKR3 atypical chemokine receptor 3
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BSG basigin (Ok blood group)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD59 CD59 molecule, complement regulatory protein
CDH13 cadherin 13
CETN2 centrin, EF-hand protein, 2
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
CYBRD1 cytochrome b reductase 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETHE1 ethylmalonic encephalopathy 1
F11R F11 receptor
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFBP1 fibroblast growth factor binding protein 1
FST follistatin
GPM6A glycoprotein M6A
GSTA4 glutathione S-transferase alpha 4
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
KRT4 keratin 4, type II
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
LUM lumican
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
MSN moesin
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
NMU neuromedin U
NPTX2 neuronal pentraxin II
NTS neurotensin
NUCB1 nucleobindin 1
P3H2 prolyl 3-hydroxylase 2
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDIA3 protein disulfide isomerase family A, member 3
PGK1 phosphoglycerate kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGR SH3 domain binding glutamate-rich protein
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TAGLN2 transgelin 2
THBS2 thrombospondin 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TPMT thiopurine S-methyltransferase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC13B unc-13 homolog B (C. elegans)
VAMP3 vesicle-associated membrane protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASF1A anti-silencing function 1A histone chaperone
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CREBBP CREB binding protein
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FAM222B family with sequence similarity 222, member B
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FOXA1 forkhead box A1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GGNBP2 gametogenetin binding protein 2
GOSR1 golgi SNAP receptor complex member 1
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LIPT1 lipoyltransferase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MRFAP1L1 Morf4 family associated protein 1-like 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSH6 mutS homolog 6
N4BP2L2 NEDD4 binding protein 2-like 2
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP50 nucleoporin 50kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDS5B PDS5 cohesin associated factor B
PER2 period circadian clock 2
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSPC1 paraspeckle component 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RABIF RAB interacting factor
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RAP2B RAP2B, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RIOK2 RIO kinase 2
RNF113A ring finger protein 113A
RNF6 ring finger protein (C3H2C3 type) 6
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A6 S100 calcium binding protein A6
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEPHS1 selenophosphate synthetase 1
SETD5 SET domain containing 5
SFN stratifin
SIRT1 sirtuin 1
SIX1 SIX homeobox 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SOBP sine oculis binding protein homolog (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX2 T-box 2
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UMPS uridine monophosphate synthetase
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB1 zinc finger and BTB domain containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF443 zinc finger protein 443