BRD-A60245366_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-A60245366_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD6 abhydrolase domain containing 6
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
BLNK B-cell linker
C3 complement component 3
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDH13 cadherin 13
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CTAG2 cancer/testis antigen 2
CXADR coxsackie virus and adenovirus receptor
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FST follistatin
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LOC100272216 uncharacterized LOC100272216
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
MSN moesin
MXRA5 matrix-remodelling associated 5
MYO1D myosin ID
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PLVAP plasmalemma vesicle associated protein
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PTK2 protein tyrosine kinase 2
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RTN1 reticulon 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMC1A structural maintenance of chromosomes 1A
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACOT9 acyl-CoA thioesterase 9
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ASF1A anti-silencing function 1A histone chaperone
ASNSD1 asparagine synthetase domain containing 1
ATF1 activating transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCAS2 breast carcinoma amplified sequence 2
BCAS3 breast carcinoma amplified sequence 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT7 CCR4-NOT transcription complex, subunit 7
COIL coilin
COMMD3 COMM domain containing 3
CORO1C coronin, actin binding protein, 1C
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST3 cystatin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
FAM35A family with sequence similarity 35, member A
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
KDM5D lysine (K)-specific demethylase 5D
KRT14 keratin 14, type I
KYNU kynureninase
LARP4B La ribonucleoprotein domain family, member 4B
LXN latexin
MCM10 minichromosome maintenance complex component 10
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRPS30 mitochondrial ribosomal protein S30
MSRB2 methionine sulfoxide reductase B2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NET1 neuroepithelial cell transforming 1
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PFKP phosphofructokinase, platelet
PITRM1 pitrilysin metallopeptidase 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP6C protein phosphatase 6, catalytic subunit
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBM14 RNA binding motif protein 14
RBM39 RNA binding motif protein 39
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFK riboflavin kinase
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPP30 ribonuclease P/MRP 30kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPHS1 selenophosphate synthetase 1
SIX1 SIX homeobox 1
SLIRP SRA stem-loop interacting RNA binding protein
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM251 transmembrane protein 251
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRA2B transformer 2 beta homolog (Drosophila)
TSKU tsukushi, small leucine rich proteoglycan
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP22 ubiquitin specific peptidase 22
WAC WW domain containing adaptor with coiled-coil
XBP1 X-box binding protein 1
YME1L1 YME1-like 1 ATPase
YTHDC1 YTH domain containing 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB11 zinc finger and BTB domain containing 11
ZDHHC6 zinc finger, DHHC-type containing 6
ZMYM2 zinc finger, MYM-type 2
ZMYND11 zinc finger, MYND-type containing 11
ZNF217 zinc finger protein 217
ZNF330 zinc finger protein 330