BRD-A60245366_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A60245366_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZU1 azurocidin 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDH13 cadherin 13
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYBRD1 cytochrome b reductase 1
DSTN destrin (actin depolymerizing factor)
EFHD1 EF-hand domain family, member D1
EIF1 eukaryotic translation initiation factor 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FYB FYN binding protein
GAS6 growth arrest-specific 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
L1CAM L1 cell adhesion molecule
LDOC1 leucine zipper, down-regulated in cancer 1
MME membrane metallo-endopeptidase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PRTN3 proteinase 3
SDC2 syndecan 2
SH3BGR SH3 domain binding glutamate-rich protein
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TMEM14B transmembrane protein 14B
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
VAMP3 vesicle-associated membrane protein 3
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ARPC5L actin related protein 2/3 complex, subunit 5-like
AURKA aurora kinase A
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF169 chromosome 14 open reading frame 169
CCNA2 cyclin A2
CCNF cyclin F
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EPS8 epidermal growth factor receptor pathway substrate 8
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GGNBP2 gametogenetin binding protein 2
GNAS GNAS complex locus
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
INTS5 integrator complex subunit 5
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NRN1 neuritin 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PWP1 PWP1 homolog (S. cerevisiae)
RBM15 RNA binding motif protein 15
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAFB2 scaffold attachment factor B2
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPX2 TPX2, microtubule-associated
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UMPS uridine monophosphate synthetase
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WBP5 WW domain binding protein 5
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF22 zinc finger protein 22