BRD-A60245366_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A60245366_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
APLP2 amyloid beta (A4) precursor-like protein 2
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CFH complement factor H
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP7 fatty acid binding protein 7, brain
FAM63A family with sequence similarity 63, member A
FASN fatty acid synthase
FGFR4 fibroblast growth factor receptor 4
FKBP9 FK506 binding protein 9, 63 kDa
FLT1 fms-related tyrosine kinase 1
GAA glucosidase, alpha; acid
GPC4 glypican 4
GPM6A glycoprotein M6A
GRN granulin
HCAR3 hydroxycarboxylic acid receptor 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT4 keratin 4, type II
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NMU neuromedin U
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P3H2 prolyl 3-hydroxylase 2
PDLIM1 PDZ and LIM domain 1
PFKM phosphofructokinase, muscle
PLCB4 phospholipase C, beta 4
PLSCR3 phospholipid scramblase 3
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTN pleiotrophin
RGS10 regulator of G-protein signaling 10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNX10 sorting nexin 10
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM45A transmembrane protein 45A
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AMD1 adenosylmethionine decarboxylase 1
ATMIN ATM interactor
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDC5L cell division cycle 5-like
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
COPS2 COP9 signalosome subunit 2
CSRP1 cysteine and glycine-rich protein 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM208B family with sequence similarity 208, member B
FOSL1 FOS-like antigen 1
GCH1 GTP cyclohydrolase 1
GGNBP2 gametogenetin binding protein 2
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KIAA0907 KIAA0907
KIF1BP KIF1 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PALB2 partner and localizer of BRCA2
PLN phospholamban
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRPF4B pre-mRNA processing factor 4B
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RANBP2 RAN binding protein 2
RBM15 RNA binding motif protein 15
RNF111 ring finger protein 111
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SCAF8 SR-related CTD-associated factor 8
SETD5 SET domain containing 5
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD7 SMAD family member 7
SMNDC1 survival motor neuron domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC1 transforming, acidic coiled-coil containing protein 1
TATDN2 TatD DNase domain containing 2
TBP TATA box binding protein
TBX3 T-box 3
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF165 zinc finger protein 165
ZNF189 zinc finger protein 189