BRD-A60245366_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-A60245366_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPTL2 angiopoietin-like 2
BLNK B-cell linker
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CAV2 caveolin 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLCA4 chloride channel accessory 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
FABP6 fatty acid binding protein 6, ileal
FAM63A family with sequence similarity 63, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
GPM6A glycoprotein M6A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIAA0226L KIAA0226-like
KIAA1462 KIAA1462
KRT20 keratin 20, type I
LAMA4 laminin, alpha 4
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NGRN neugrin, neurite outgrowth associated
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PGK1 phosphoglycerate kinase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL4A ADP-ribosylation factor-like 4A
ARMCX6 armadillo repeat containing, X-linked 6
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BLCAP bladder cancer associated protein
BLVRA biliverdin reductase A
BRD3 bromodomain containing 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPA centromere protein A
CHIC2 cysteine-rich hydrophobic domain 2
CRY1 cryptochrome circadian clock 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
EHD1 EH-domain containing 1
EMP3 epithelial membrane protein 3
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GOLM1 golgi membrane protein 1
GRWD1 glutamate-rich WD repeat containing 1
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
JMJD6 jumonji domain containing 6
KIAA0368 KIAA0368
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOSIP nitric oxide synthase interacting protein
NRIP1 nuclear receptor interacting protein 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
OSER1 oxidative stress responsive serine-rich 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RHOF ras homolog family member F (in filopodia)
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPP30 ribonuclease P/MRP 30kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SRRD SRR1 domain containing
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TUBA4A tubulin, alpha 4a
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZDHHC6 zinc finger, DHHC-type containing 6
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF146 zinc finger protein 146