BRD-A60245366_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A60245366_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM9 ADAM metallopeptidase domain 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3D CD3d molecule, delta (CD3-TCR complex)
CD47 CD47 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC10A C-type lectin domain family 10, member A
CLIC5 chloride intracellular channel 5
CLIP3 CAP-GLY domain containing linker protein 3
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CRIP2 cysteine-rich protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSB cathepsin B
CTSS cathepsin S
CXCL13 chemokine (C-X-C motif) ligand 13
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H1C histone cluster 1, H1c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
HSPG2 heparan sulfate proteoglycan 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MYLK myosin light chain kinase
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PCP4 Purkinje cell protein 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS1 regulator of G-protein signaling 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOX17 SRY (sex determining region Y)-box 17
SULF1 sulfatase 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRBC1 T cell receptor beta constant 1
VWF von Willebrand factor
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
COPS7A COP9 signalosome subunit 7A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EIF4B eukaryotic translation initiation factor 4B
EXOSC4 exosome component 4
FA2H fatty acid 2-hydroxylase
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KRT6B keratin 6B, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LONP2 lon peptidase 2, peroxisomal
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MTF2 metal response element binding transcription factor 2
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOSIP nitric oxide synthase interacting protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPL38 ribosomal protein L38
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC25A46 solute carrier family 25, member 46
SNRPE small nuclear ribonucleoprotein polypeptide E
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
UGCG UDP-glucose ceramide glucosyltransferase