BRD-A59985574_T542500_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

279 genes differentially expressed following the BRD-A59985574_T542500_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AGA aspartylglucosaminidase
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
ANXA9 annexin A9
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CAPG capping protein (actin filament), gelsolin-like
CD46 CD46 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CXCL2 chemokine (C-X-C motif) ligand 2
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EXPH5 exophilin 5
FAM149A family with sequence similarity 149, member A
FBLN1 fibulin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHOD3 formin homology 2 domain containing 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GLO1 glyoxalase I
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-C major histocompatibility complex, class I, C
HTRA1 HtrA serine peptidase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
ITGB5 integrin, beta 5
ITGB7 integrin, beta 7
KIAA0226L KIAA0226-like
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MAOB monoamine oxidase B
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NUCB1 nucleobindin 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
OVGP1 oviductal glycoprotein 1, 120kDa
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBX3 pre-B-cell leukemia homeobox 3
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG2 secretogranin II
SELENBP1 selenium binding protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAB1 stabilin 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCF21 transcription factor 21
TEK TEK tyrosine kinase, endothelial
TMEM14A transmembrane protein 14A
TMEM176A transmembrane protein 176A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUSC3 tumor suppressor candidate 3
TYRP1 tyrosinase-related protein 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADGRE5 adhesion G protein-coupled receptor E5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AGO2 argonaute RISC catalytic component 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BAG5 BCL2-associated athanogene 5
BARD1 BRCA1 associated RING domain 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRPF1 bromodomain and PHD finger containing, 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHRDL1 chordin-like 1
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CUL2 cullin 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DAAM1 dishevelled associated activator of morphogenesis 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DCP1A decapping mRNA 1A
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DUSP4 dual specificity phosphatase 4
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF5 eukaryotic translation initiation factor 5
ELOVL2 ELOVL fatty acid elongase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FBXO11 F-box protein 11
FGF13 fibroblast growth factor 13
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABPB1 GA binding protein transcription factor, beta subunit 1
GMDS GDP-mannose 4,6-dehydratase
GOLGA8A golgin A8 family, member A
GOSR1 golgi SNAP receptor complex member 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HJURP Holliday junction recognition protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXA10 homeobox A10
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
KYNU kynureninase
LPIN1 lipin 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MED6 mediator complex subunit 6
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MTF2 metal response element binding transcription factor 2
N4BP2L2 NEDD4 binding protein 2-like 2
NCAPG non-SMC condensin I complex, subunit G
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOTCH2NL notch 2 N-terminal like
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUPL1 nucleoporin like 1
PARP2 poly (ADP-ribose) polymerase 2
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PLIN1 perilipin 1
PLK1 polo-like kinase 1
POLQ polymerase (DNA directed), theta
PPARG peroxisome proliferator-activated receptor gamma
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RBM25 RNA binding motif protein 25
RFC3 replication factor C (activator 1) 3, 38kDa
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RREB1 ras responsive element binding protein 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY2 RUN and FYVE domain containing 2
SACS sacsin molecular chaperone
SAR1A secretion associated, Ras related GTPase 1A
SASH1 SAM and SH3 domain containing 1
SAV1 salvador family WW domain containing protein 1
SCAF4 SR-related CTD-associated factor 4
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNW1 SNW domain containing 1
SNX11 sorting nexin 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STIL SCL/TAL1 interrupting locus
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBP TATA box binding protein
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TNPO2 transportin 2
TSC22D2 TSC22 domain family, member 2
TTK TTK protein kinase
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND6 zinc finger, AN1-type domain 6
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131