BRD-A59145032_-666_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-A59145032_-666_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BAG3 BCL2-associated athanogene 3
CD163 CD163 molecule
CD52 CD52 molecule
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
GCLM glutamate-cysteine ligase, modifier subunit
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
PRAME preferentially expressed antigen in melanoma
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TPM2 tropomyosin 2 (beta)
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
G0S2 G0/G1 switch 2
GNLY granulysin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
NKG7 natural killer cell granule protein 7
PBX1 pre-B-cell leukemia homeobox 1
PTCH1 patched 1
RGS2 regulator of G-protein signaling 2
SLPI secretory leukocyte peptidase inhibitor
STOM stomatin
TFF1 trefoil factor 1
TSPAN12 tetraspanin 12