BRD-A59145032_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A59145032_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AZU1 azurocidin 1
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
COL4A5 collagen, type IV, alpha 5
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HBD hemoglobin, delta
HMOX1 heme oxygenase 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MIR22HG MIR22 host gene
NAMPT nicotinamide phosphoribosyltransferase
NCOA2 nuclear receptor coactivator 2
OLFM4 olfactomedin 4
PERP PERP, TP53 apoptosis effector
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STOM stomatin
SYT1 synaptotagmin I
TMEM2 transmembrane protein 2
TRIM29 tripartite motif containing 29
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
BIRC5 baculoviral IAP repeat containing 5
C6ORF62 chromosome 6 open reading frame 62
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CLDN10 claudin 10
CREB1 cAMP responsive element binding protein 1
DEFB1 defensin, beta 1
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
EIF4B eukaryotic translation initiation factor 4B
EVL Enah/Vasp-like
FMO3 flavin containing monooxygenase 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HEBP1 heme binding protein 1
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIF14 kinesin family member 14
LMNB1 lamin B1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MED21 mediator complex subunit 21
MREG melanoregulin
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TCF4 transcription factor 4
UBE2C ubiquitin-conjugating enzyme E2C
XYLT1 xylosyltransferase I