BRD-A59145032_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-A59145032_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ANPEP alanyl (membrane) aminopeptidase
ARHGAP32 Rho GTPase activating protein 32
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD200 CD200 molecule
CD300A CD300a molecule
CD52 CD52 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
EN1 engrailed homeobox 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL1 four and a half LIM domains 1
FMO3 flavin containing monooxygenase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FPR1 formyl peptide receptor 1
FXYD6 FXYD domain containing ion transport regulator 6
GATA2 GATA binding protein 2
GMFG glia maturation factor, gamma
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL10RA interleukin 10 receptor, alpha
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MT1M metallothionein 1M
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD5 stearoyl-CoA desaturase 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOX11 SRY (sex determining region Y)-box 11
SSPN sarcospan
STON1 stonin 1
TBX3 T-box 3
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TYROBP TYRO protein tyrosine kinase binding protein
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
XCL1 chemokine (C motif) ligand 1
ZNF292 zinc finger protein 292
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALCAM activated leukocyte cell adhesion molecule
ANXA7 annexin A7
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
B3GNT1
BLVRA biliverdin reductase A
BST2 bone marrow stromal cell antigen 2
C5ORF15 chromosome 5 open reading frame 15
CBR3 carbonyl reductase 3
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CHPT1 choline phosphotransferase 1
COG2 component of oligomeric golgi complex 2
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IL6ST interleukin 6 signal transducer
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGED1 melanoma antigen family D1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOTCH2 notch 2
NUP98 nucleoporin 98kDa
PDGFC platelet derived growth factor C
PEBP1 phosphatidylethanolamine binding protein 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTTG1 pituitary tumor-transforming 1
RAB4A RAB4A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCAN1 regulator of calcineurin 1
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SRPX sushi-repeat containing protein, X-linked
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMCO3 transmembrane and coiled-coil domains 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TSPAN3 tetraspanin 3
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UXS1 UDP-glucuronate decarboxylase 1
WFDC2 WAP four-disulfide core domain 2
ZMAT3 zinc finger, matrin-type 3
ZNF185 zinc finger protein 185 (LIM domain)