BRD-A58767537_afatinib_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-A58767537_afatinib_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
ARHGAP29 Rho GTPase activating protein 29
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BBS1 Bardet-Biedl syndrome 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
C9ORF91 chromosome 9 open reading frame 91
CCDC28A coiled-coil domain containing 28A
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
EAPP E2F-associated phosphoprotein
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GRN granulin
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IFITM1 interferon induced transmembrane protein 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIAA1324 KIAA1324
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
MLPH melanophilin
MME membrane metallo-endopeptidase
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PCCA propionyl CoA carboxylase, alpha polypeptide
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRSS8 protease, serine, 8
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SEPHS2 selenophosphate synthetase 2
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF3 trefoil factor 3 (intestinal)
TNNT1 troponin T type 1 (skeletal, slow)
TOM1L1 target of myb1 (chicken)-like 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TXNIP thioredoxin interacting protein
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATAD2 ATPase family, AAA domain containing 2
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CD52 CD52 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CTPS1 CTP synthase 1
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
DUSP2 dual specificity phosphatase 2
EMP1 epithelial membrane protein 1
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
GNAS GNAS complex locus
GPC3 glypican 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INA internexin neuronal intermediate filament protein, alpha
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KYNU kynureninase
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MSMO1 methylsterol monooxygenase 1
NELL2 NEL-like 2 (chicken)
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
RCAN2 regulator of calcineurin 2
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SRM spermidine synthase
STMN2 stathmin 2
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)