BRD-A58767537_afatinib_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A58767537_afatinib_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AKAP9 A kinase (PRKA) anchor protein 9
AMIGO2 adhesion molecule with Ig-like domain 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP9A ATPase, class II, type 9A
C3AR1 complement component 3a receptor 1
CA4 carbonic anhydrase IV
CAPN1 calpain 1, (mu/I) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CERK ceramide kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CTSS cathepsin S
DEPTOR DEP domain containing MTOR-interacting protein
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
GLUL glutamate-ammonia ligase
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HP haptoglobin
LOC100272216 uncharacterized LOC100272216
MPO myeloperoxidase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MVP major vault protein
OBSL1 obscurin-like 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLTP phospholipid transfer protein
PPAP2C phosphatidic acid phosphatase type 2C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SLC35E2B solute carrier family 35, member E2B
SPDEF SAM pointed domain containing ETS transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC2 stanniocalcin 2
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
USP9X ubiquitin specific peptidase 9, X-linked
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZNF551 zinc finger protein 551
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IL1RN interleukin 1 receptor antagonist
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MAL mal, T-cell differentiation protein
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NEB nebulin
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP85 nucleoporin 85kDa
PCDH9 protocadherin 9
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SIVA1 SIVA1, apoptosis-inducing factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM38B transmembrane protein 38B
TRIP13 thyroid hormone receptor interactor 13
TTN titin
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)