BRD-A58767537_afatinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A58767537_afatinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
CLU clusterin
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
OLFM1 olfactomedin 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
SDC2 syndecan 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SULF1 sulfatase 1
TCF4 transcription factor 4
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BIK BCL2-interacting killer (apoptosis-inducing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CLDN4 claudin 4
CRISP3 cysteine-rich secretory protein 3
CSNK1E casein kinase 1, epsilon
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HOXA10 homeobox A10
IER2 immediate early response 2
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1B interleukin 1, beta
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
LAMC2 laminin, gamma 2
LGALS2 lectin, galactoside-binding, soluble, 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NOP56 NOP56 ribonucleoprotein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
SCG5 secretogranin V
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
THBD thrombomodulin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36L1 ZFP36 ring finger protein-like 1