BRD-A58767537_afatinib_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-A58767537_afatinib_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATF3 activating transcription factor 3
ATXN1 ataxin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCNG2 cyclin G2
CD99 CD99 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP57 centrosomal protein 57kDa
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
GATA3 GATA binding protein 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HSPB8 heat shock 22kDa protein 8
IRS2 insulin receptor substrate 2
KRT15 keratin 15, type I
LPL lipoprotein lipase
LY75 lymphocyte antigen 75
MEF2C myocyte enhancer factor 2C
NEBL nebulette
OSR2 odd-skipped related transciption factor 2
OXTR oxytocin receptor
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS5 regulator of G-protein signaling 5
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNM synemin, intermediate filament protein
TBX2 T-box 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
AK1 adenylate kinase 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CHGB chromogranin B
COMP cartilage oligomeric matrix protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAP fibroblast activation protein, alpha
FOSL1 FOS-like antigen 1
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HBEGF heparin-binding EGF-like growth factor
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAI14 retinoic acid induced 14
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPP1 secreted phosphoprotein 1
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TSPAN4 tetraspanin 4
TXNDC9 thioredoxin domain containing 9
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)