BRD-A58767537_afatinib_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A58767537_afatinib_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASS1 argininosuccinate synthase 1
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C6ORF62 chromosome 6 open reading frame 62
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CP ceruloplasmin (ferroxidase)
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
H3F3B H3 histone, family 3B (H3.3B)
LBP lipopolysaccharide binding protein
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUPR1 nuclear protein, transcriptional regulator, 1
PALMD palmdelphin
PCSK6 proprotein convertase subtilisin/kexin type 6
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTCH1 patched 1
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RELN reelin
RPL37A ribosomal protein L37a
SESN1 sestrin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDO2 tryptophan 2,3-dioxygenase
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ACVR1 activin A receptor, type I
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AREG amphiregulin
AXL AXL receptor tyrosine kinase
BID BH3 interacting domain death agonist
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDCP1 CUB domain containing protein 1
CHIC2 cysteine-rich hydrophobic domain 2
COBL cordon-bleu WH2 repeat protein
COG7 component of oligomeric golgi complex 7
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
KRT13 keratin 13, type I
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTA4H leukotriene A4 hydrolase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPY1R neuropeptide Y receptor Y1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PSD3 pleckstrin and Sec7 domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
UPP1 uridine phosphorylase 1