BRD-A58767537_afatinib_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A58767537_afatinib_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASS1 argininosuccinate synthase 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C9ORF3 chromosome 9 open reading frame 3
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CLIC3 chloride intracellular channel 3
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CST3 cystatin C
CTSD cathepsin D
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
E2F2 E2F transcription factor 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HEG1 heart development protein with EGF-like domains 1
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IGFBP3 insulin-like growth factor binding protein 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK3 potassium channel, two pore domain subfamily K, member 3
L1CAM L1 cell adhesion molecule
LBH limb bud and heart development
LBP lipopolysaccharide binding protein
LEFTY1 left-right determination factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
LMOD1 leiomodin 1 (smooth muscle)
LYN LYN proto-oncogene, Src family tyrosine kinase
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MPZL1 myelin protein zero-like 1
MYH10 myosin, heavy chain 10, non-muscle
NLRP2 NLR family, pyrin domain containing 2
NXN nucleoredoxin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPAP2A phosphatidic acid phosphatase type 2A
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB40B RAB40B, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
S100A7 S100 calcium binding protein A7
SCG5 secretogranin V
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIDT2 SID1 transmembrane family, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN2 stathmin 2
TFF3 trefoil factor 3 (intestinal)
TNS1 tensin 1
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VWF von Willebrand factor

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASPH aspartate beta-hydroxylase
BCL2A1 BCL2-related protein A1
BZW1 basic leucine zipper and W2 domains 1
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLEC2B C-type lectin domain family 2, member B
CRABP2 cellular retinoic acid binding protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
ETV1 ets variant 1
ETV5 ets variant 5
GK glycerol kinase
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VEGFA vascular endothelial growth factor A