BRD-A58767537_afatinib_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

39 genes differentially expressed following the BRD-A58767537_afatinib_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAMBI BMP and activin membrane-bound inhibitor
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
DLK1 delta-like 1 homolog (Drosophila)
FBXO21 F-box protein 21
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAN1A1 mannosidase, alpha, class 1A, member 1
PRKCI protein kinase C, iota
PTGIS prostaglandin I2 (prostacyclin) synthase
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC38A1 solute carrier family 38, member 1
SPP1 secreted phosphoprotein 1
STOM stomatin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
APOLD1 apolipoprotein L domain containing 1
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GATA3 GATA binding protein 3
HBEGF heparin-binding EGF-like growth factor
KDM5D lysine (K)-specific demethylase 5D
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A4 S100 calcium binding protein A4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1