BRD-A58767537_afatinib_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A58767537_afatinib_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG2 adhesion G protein-coupled receptor G2
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CLU clusterin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFS embryonal Fyn-associated substrate
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GABARAPL1 GABA(A) receptor-associated protein like 1
GLUL glutamate-ammonia ligase
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
GSTT1 glutathione S-transferase theta 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPB8 heat shock 22kDa protein 8
KIAA0226L KIAA0226-like
LYN LYN proto-oncogene, Src family tyrosine kinase
METTL7A methyltransferase like 7A
MXRA5 matrix-remodelling associated 5
NRBF2 nuclear receptor binding factor 2
PTN pleiotrophin
QKI QKI, KH domain containing, RNA binding
RAB31 RAB31, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D3 TSC22 domain family, member 3
TYMP thymidine phosphorylase
VCAN versican
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
L1CAM L1 cell adhesion molecule
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAT ornithine aminotransferase
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
SFRP1 secreted frizzled-related protein 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRED2 sprouty-related, EVH1 domain containing 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TUBB6 tubulin, beta 6 class V