BRD-A58767537_afatinib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-A58767537_afatinib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BST2 bone marrow stromal cell antigen 2
CCDC69 coiled-coil domain containing 69
CFB complement factor B
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOXO4 forkhead box O4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
KDM3A lysine (K)-specific demethylase 3A
KRCC1 lysine-rich coiled-coil 1
KRT15 keratin 15, type I
LTF lactotransferrin
MERTK MER proto-oncogene, tyrosine kinase
MIR22HG MIR22 host gene
MSL1 male-specific lethal 1 homolog (Drosophila)
MTMR11 myotubularin related protein 11
NEU1 sialidase 1 (lysosomal sialidase)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZD2 PDZ domain containing 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX11A peroxisomal biogenesis factor 11 alpha
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG6 adhesion G protein-coupled receptor G6
AK4 adenylate kinase 4
ARHGAP29 Rho GTPase activating protein 29
AXL AXL receptor tyrosine kinase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CLTB clathrin, light chain B
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBRD1 cytochrome b reductase 1
DCLK1 doublecortin-like kinase 1
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
HHEX hematopoietically expressed homeobox
HOPX HOP homeobox
IER3 immediate early response 3
ITGA6 integrin, alpha 6
LAPTM4B lysosomal protein transmembrane 4 beta
MGLL monoglyceride lipase
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPIF peptidylprolyl isomerase F
PRDX4 peroxiredoxin 4
QDPR quinoid dihydropteridine reductase
S100A2 S100 calcium binding protein A2
SLC43A3 solute carrier family 43, member 3
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TGFA transforming growth factor, alpha
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TYMS thymidylate synthetase