BRD-A58564983_SELAMECTIN_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A58564983_SELAMECTIN_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ATF3 activating transcription factor 3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHIC2 cysteine-rich hydrophobic domain 2
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INHBA inhibin, beta A
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM30B transmembrane protein 30B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
UVRAG UV radiation resistance associated
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC8 zinc finger, CCHC domain containing 8
ZEB2 zinc finger E-box binding homeobox 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AOX1 aldehyde oxidase 1
B3GNT1
BAX BCL2-associated X protein
BST2 bone marrow stromal cell antigen 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
CDC25B cell division cycle 25B
CFB complement factor B
CKB creatine kinase, brain
CP ceruloplasmin (ferroxidase)
CYTL1 cytokine-like 1
FHL1 four and a half LIM domains 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HDDC2 HD domain containing 2
HLF hepatic leukemia factor
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
MCAM melanoma cell adhesion molecule
NMU neuromedin U
NPY neuropeptide Y
NREP neuronal regeneration related protein
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCSK6 proprotein convertase subtilisin/kexin type 6
POSTN periostin, osteoblast specific factor
PPL periplakin
PRDX1 peroxiredoxin 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
TPM1 tropomyosin 1 (alpha)
VCAN versican