BRD-A58564983_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

280 genes differentially expressed following the BRD-A58564983_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TUFT1 tuftelin 1
VCPKMT valosin containing protein lysine (K) methyltransferase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF160 zinc finger protein 160
ZNF195 zinc finger protein 195
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT1 acetyl-CoA acetyltransferase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AXL AXL receptor tyrosine kinase
B3GNT1
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CCNG1 cyclin G1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COPS7A COP9 signalosome subunit 7A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRTAP cartilage associated protein
CST3 cystatin C
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FADS1 fatty acid desaturase 1
FAM111A family with sequence similarity 111, member A
FAM35A family with sequence similarity 35, member A
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GLB1 galactosidase, beta 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLM1 golgi membrane protein 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KANK2 KN motif and ankyrin repeat domains 2
KCTD12 potassium channel tetramerization domain containing 12
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM1A lysine (K)-specific demethylase 1A
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
MAGED1 melanoma antigen family D1
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKI67 marker of proliferation Ki-67
NIT2 nitrilase family, member 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO2 NAD(P)H dehydrogenase, quinone 2
NUSAP1 nucleolar and spindle associated protein 1
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PGM1 phosphoglucomutase 1
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRC1 protein regulator of cytokinesis 1
PRDX4 peroxiredoxin 4
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
S100A4 S100 calcium binding protein A4
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMS spermine synthase
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN1 stathmin 1
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF2 transmembrane 9 superfamily member 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta